A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

@inproceedings{Shi2019ASM,
  title={A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development},
  author={Yuanyuan Shi and Xiaoqing Hu and Jin Cheng and Xin Zhang and Fengyuan Zhao and Weili Shi and Bo Ren and Huilei Yu and Peng Yang and Zong Li and Qiang Liu and Zhenlong Liu and Xiaoning Duan and Xin Fu and Jiying Zhang and Jianquan Wang and Yingfang Ao},
  booktitle={Nature Communications},
  year={2019}
}
Degradation of extracellular matrix (ECM) underlies loss of cartilage tissue in osteoarthritis, a common disease for which no effective disease-modifying therapy currently exists. Here we describe BNTA, a small molecule with ECM modulatory properties. BNTA promotes generation of ECM components in cultured chondrocytes isolated from individuals with osteoarthritis. In human osteoarthritic cartilage explants, BNTA treatment stimulates expression of ECM components while suppressing inflammatory… CONTINUE READING

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