A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.

Abstract

High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiologic factor in prostate cancer (CaP) occurrence, recurrence, and progression. Androgen induces ROS production in the prostate by a yet unknown mechanism. Here, to the best of our knowledge, we report for the first time that androgen induces an… (More)
DOI: 10.1158/0008-5472.CAN-08-2472

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@article{Basu2009ASM, title={A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.}, author={Hirak S. Basu and Todd Thompson and Dawn R. Church and Cynthia C Clower and Farideh Mehraein-Ghomi and Corey A Amlong and Christopher T. Martin and Patrick M. Woster and Mary J. Lindstrom and George Wilding}, journal={Cancer research}, year={2009}, volume={69 19}, pages={7689-95} }