A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells.

@article{Chen2009ASM,
  title={A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells.},
  author={Yu-Jen Chen and Wei-Min Chang and Yi-wen Liu and Chia-Yun Lee and Y Jang and Cheng-Deng Kuo and Hui-Fen Liao},
  journal={Chemico-biological interactions},
  year={2009},
  volume={181 3},
  pages={440-6}
}
Norcantharidin (NCTD) is a small-molecule metastasis inhibitor without renal toxicity derived from a renal toxic compound cantharidin, which is found in blister beetles (Mylabris phalerata Pall.), commonly used in traditional Chinese medicine. The anti-metastatic capacity of NCTD is apparently through the downexpression of matrix metalloproteinase-9 (MMP-9) activity. The aim of this study was to clarify the transcriptional regulation of MMP-9 gene by NCTD in colorectal cancer CT-26 cells. NCTD… CONTINUE READING

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