A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

@article{Green2016ASI,
  title={A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice},
  author={Eric M. Green and Hiroko Wakimoto and Robert L. Anderson and Marc J. Evanchik and Joshua M. Gorham and Brooke C. Harrison and Marcus Henze and Raja F Kawas and Johan D. Oslob and Hector M. Rodriguez and Yonghong Song and William Wan and L. A. Leinwand and James A Spudich and Robert S. McDowell and Jonathan G Seidman and Christine E Seidman},
  journal={Science},
  year={2016},
  volume={351},
  pages={617-621}
}
Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be caused by mutations in sarcomere proteins. Clinical diagnosis depends on an abnormal thickening of the heart, but the earliest signs of disease are hyperdynamic contraction and impaired relaxation. Whereas some in vitro studies of power generation by mutant and wild-type sarcomere proteins are consistent with mutant sarcomeres exhibiting enhanced contractile power, others are not. We identified a small… CONTINUE READING
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