A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease.

@article{Kithcart2010ASI,
  title={A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease.},
  author={Aaron P. Kithcart and Gina Mavrikis Cox and Thais M Sielecki and Abigail E. Short and James Pruitt and Tracey L. Papenfuss and Todd M. Shawler and Ingrid E. Gienapp and Abhay R Satoskar and Caroline C. Whitacre},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 11},
  pages={4459-66}
}
Multiple sclerosis (MS) is a chronic, debilitating disease of the central nervous system (CNS) characterized by demyelination and axon loss. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) has been shown to be elevated in the cerebrospinal fluid of patients during relapses. The purpose of this study was to evaluate a new small-molecule inhibitor of MIF and its ability to reduce the severity of an animal model of MS, experimental autoimmune encephalomyelitis (EAE). We… CONTINUE READING