A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.

@article{Liu2012ASI,
  title={A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.},
  author={Yi Liu and Yanyan Cao and Weihe Zhang and Stephen C. Bergmeier and Yanrong Qian and Huzoor Akbar and Robert Colvin and Juan Ding and Lingying Tong and Shiyong Wu and Jennifer Hines and Xiaozhuo Chen},
  journal={Molecular cancer therapeutics},
  year={2012},
  volume={11 8},
  pages={1672-82}
}
The functional and therapeutic importance of the Warburg effect is increasingly recognized, and glycolysis has become a target of anticancer strategies. We recently reported the identification of a group of novel small compounds that inhibit basal glucose transport and reduce cancer cell growth by a glucose deprivation-like mechanism. We hypothesized that the compounds target Glut1 and are efficacious in vivo as anticancer agents. Here, we report that a novel representative compound WZB117 not… CONTINUE READING
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