A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

@inproceedings{Cheng2014ASI,
  title={A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways},
  author={Jin Cheng and Y Fan and Xueping Xu and Huiyuan Zhang and Jun Dou and Yiyuan Tang and Xinping Zhong and Yesenia Rojas and Yonghao Yu and Yang Zhao and Sanjeev A. Vasudevan and Jed G. Nuchtern and Eugene S. Kim and Xing Chen and Falong Lu and Jianhua Yang},
  booktitle={Cell Death and Disease},
  year={2014}
}
Neuroblastoma (NB) is the most common extracranial neoplasm in children. In NB, loss of p53 function is largely due to cytoplasmic sequestration rather than mutation. Ubiquitin-conjugating enzyme E2 N (UBE2N), also known as Ubc13, is an E2 ubiquitin-conjugating enzyme that promotes formation of monomeric p53 that results in its cytoplasmic translocation and subsequent loss of function. Therefore, inhibition of UBE2N may reactivate p53 by promoting its nuclear accumulation. Here, we show that… CONTINUE READING