A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness.

@article{Coppola2008ASF,
  title={A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness.},
  author={Julia M Coppola and Mahaveer Swaroop Bhojani and Brian D. Ross and Alnawaz Rehemtulla},
  journal={Neoplasia},
  year={2008},
  volume={10 4},
  pages={
          363-70
        }
}
  • Julia M Coppola, Mahaveer Swaroop Bhojani, +1 author Alnawaz Rehemtulla
  • Published in Neoplasia 2008
  • Biology, Medicine
  • Furin, a member the proprotein convertase (PC) family, processes inactive precursor proteins to functional proteins within the Golgi/trans-Golgi network secretory pathway. Furin and other PC family members (furin/PCs) activate proteins vital to proper physiological functioning, including growth factors and hormones, receptors, plasma proteins, and matrix metalloproteases (MMPs). Additionally, the expression and activity of furin/PC are necessary for processing substrates important for cell… CONTINUE READING

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