A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits

Abstract

BMS-262084 is a 4-carboxy-2-azetidinone-containing irreversible inhibitor of FXIa, which is selective over other coagulation proteases. We evaluated the in vitro and in vivo properties of BMS-262084 in rabbits. Studies were conducted in arteriovenous-shunt thrombosis (AVST), venous thrombosis (VT), electrolytic-mediated carotid arterial thrombosis (ECAT… (More)
DOI: 10.1007/s11239-011-0599-0

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@article{Wong2011ASF, title={A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits}, author={Pancras C. Wong and Earl J. Crain and Carol A. Watson and William A. Schumacher}, journal={Journal of Thrombosis and Thrombolysis}, year={2011}, volume={32}, pages={129-137} }