A small molecule compound inhibits AKT pathway in ovarian cancer cell lines.

@article{Tang2006ASM,
  title={A small molecule compound inhibits AKT pathway in ovarian cancer cell lines.},
  author={Huai-jing Tang and Xiaohong Jin and Shaomeng Wang and Dajun Yang and Yeyu Cao and Jianyong Chen and Dana Gossett and Jiayuh Lin},
  journal={Gynecologic oncology},
  year={2006},
  volume={100 2},
  pages={308-17}
}
BACKGROUND AND OBJECTIVE Overactivation of AKT1 and gene amplification of AKT2 are frequently detected in ovarian cancer. Activated AKT kinases provide a cell survival signal that may confer resistance to apoptosis induced by conventional therapies in cancer cells. Therefore, development of potent inhibitors that block AKT pathway is an attractive therapeutic strategy for treating ovarian carcinoma. METHODS Ovarian cancer cell lines, A2780, MDAH2774, OVCAR-8, Caov-3, and normal murine… CONTINUE READING

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