A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent.

@article{Bray1994ASE,
  title={A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent.},
  author={Macey Bray and Swati Prasad and John Dubay and Eric Hunter and K T Jeang and David Rekosh and M L Hammarskj{\"o}ld},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 4},
  pages={1256-60}
}
Replication of human immunodeficiency virus type 1 (HIV-1) is dependent on the viral Rev protein. This protein acts in concert with the cis-acting rev-responsive element present in intron-containing RNAs to facilitate nuclear export of these RNAs. Here we show that a cis-acting 219-nucleotide sequence from an unrelated "simple" retrovirus, Mason-Pfizer monkey virus (MPMV), enables Rev-independent HIV-1 replication. This sequence is present in an untranslated region near the 3' end of the MPMV… CONTINUE READING
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