A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects

@article{Fujino2010ASD,
  title={A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects},
  author={Masahiro Fujino and Shin-ichiro Miura and Yoshihiro Kiya and Yukio Tominaga and Yoshino Matsuo and Sadashiva S Karnik and Keijiro Saku},
  journal={Hypertension Research},
  year={2010},
  volume={33},
  pages={1044-1052}
}
Angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) induce multiple pharmacological beneficial effects, but not all ARBs have the same effects and the molecular mechanisms underlying their actions are not certain. In this study, irbesartan and losartan were examined because of their different molecular structures (irbesartan has a cyclopentyl group whereas losartan has a chloride group). We analyzed the binding affinity and production of inositol phosphate (IP), monocyte… CONTINUE READING
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