A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription.

  title={A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription.},
  author={Paul R Bohjanen and R A Colvin and M. Puttaraju and Michael D. Been and Mariano A. Garcia-Blanco},
  journal={Nucleic acids research},
  volume={24 19},
Linear TAR RNA has previously been used as a decoy to inhibit HIV-1 transcription in vitro and HIV-1 replication in vivo. A 48 nucleotide circular RNA containing the stem, bulge and loop of the HIV-1 TAR element was synthesized using the self-splicing activity of a group I permuted intron-exon and was tested for its ability to function as a TAR decoy in vitro. This small circular TAR molecule was exceptionally stable in HeLa nuclear extracts, whereas a similar linear TAR molecule was rapidly… CONTINUE READING
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