A small RNA activates CFA synthase by isoform-specific mRNA stabilization.

  title={A small RNA activates CFA synthase by isoform-specific mRNA stabilization.},
  author={Kathrin Sophie Fr{\"o}hlich and Kai Papenfort and Agnes Fekete and J{\"o}rg Vogel},
  journal={The EMBO journal},
  volume={32 22},
Small RNAs use a diversity of well-characterized mechanisms to repress mRNAs, but how they activate gene expression at the mRNA level remains not well understood. The predominant activation mechanism of Hfq-associated small RNAs has been translational control whereby base pairing with the target prevents the formation of an intrinsic inhibitory structure in the mRNA and promotes translation initiation. Here, we report a translation-independent mechanism whereby the small RNA RydC selectively… CONTINUE READING
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Assigning functions to Hfq-dependent small RNAs in the model pathogen Salmonella Typhimurium

  • KS Fröhlich
  • Doctoral Thesis
  • 2013
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