A small C-terminal sequence of Aurora B is responsible for localization and function.

@article{Scrittori2005ASC,
  title={A small C-terminal sequence of Aurora B is responsible for localization and function.},
  author={Laetitia Scrittori and Dimitrios A. Skoufias and Fabienne Hans and V{\'e}ronique Gerson and Paolo Sassone-Corsi and Stefan Dimitrov and Robert L. Margolis},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 1},
  pages={
          292-305
        }
}
Aurora B, a protein kinase required in mitosis, localizes to inner centromeres at metaphase and the spindle midzone in anaphase and is required for proper chromosome segregation and cytokinesis. Aurora A, a paralogue of Aurora B, localizes instead to centrosomes and spindle microtubules. Except for distinct N termini, Aurora B and Aurora A have highly similar sequences. We have combined small interfering RNA (siRNA) ablation of Aurora B with overexpression of truncation mutants to investigate… CONTINUE READING