A skewed view of X chromosome inactivation.

@article{Minks2008ASV,
  title={A skewed view of X chromosome inactivation.},
  author={Jakub Minks and Wendy P Robinson and C J Brown},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 1},
  pages={
          20-3
        }
}
X chromosome inactivation involves a random choice to silence either X chromosome early in mammalian female development. Once silenced the inactive X is stably inherited through subsequent somatic cell divisions, and thus, females are generally mosaics, having a mixture of cells with one or the other parental X active. While in most females the number of cells with either X being active is roughly equal, skewing of X chromosome inactivation is observed in a percentage of women. In this issue of… CONTINUE READING

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