A sixth sense for Rab5

  title={A sixth sense for Rab5},
  author={Alexander M. van der Bliek},
  journal={Nature Cell Biology},
It has long been known that the mammalian small GTPase Rab5 is involved in clathrin-mediated endocytosis. However, most Rab5-interacting proteins are localized to endosomes rather than to the plasma membrane. A newly discovered nucleotide-exchange factor for Rab5 in Caenorhabditis elegans now provides the missing link for activating Rab5 at the plasma membrane. 

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