A site-specific mechanism for free radical induced biological damage: the essential role of redox-active transition metals.

@article{Chevion1988ASM,
  title={A site-specific mechanism for free radical induced biological damage: the essential role of redox-active transition metals.},
  author={Mordechai Mottie Chevion},
  journal={Free radical biology & medicine},
  year={1988},
  volume={5 1},
  pages={27-37}
}
The metal-mediated site-specific mechanism for free radical-induced biological damage is reviewed. According to this mechanism, cooper- or iron-binding sites on macromolecules serve as centers for repeated production of hydroxyl radicals that are generated via the Fenton reaction. The aberrations induced by superoxide, ascorbate, isouramil, and paraquat are summarized. An illustrative example is the enhancement of double-strand breaks by ascorbate/copper. Prevention of the site-specific free… CONTINUE READING

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