A site-specific endonuclease essential for mating-type switching in Saccharomyces cerevisiae.

@article{Kostriken1983ASE,
  title={A site-specific endonuclease essential for mating-type switching in Saccharomyces cerevisiae.},
  author={Richard Kostriken and Jeffrey N. Strathern and Amar J. S. Klar and James B. Hicks and Fred Heffron},
  journal={Cell},
  year={1983},
  volume={35 1},
  pages={167-74}
}
We have detected two site-specific endonucleases in strains of Saccharomyces cerevisiae. One endonuclease, which we call YZ endo, is present only in yeast strains that are undergoing mating-type interconversion. The site at which YZ endo cleaves corresponds to the in vivo double-strand break occurring at the mating-type locus in yeast undergoing mating-type interconversion. YZ endo generates a site-specific double-strand break having 4-base 3' extensions terminating in 3' hydroxyl groups. The… CONTINUE READING
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