A site-directed Staphylococcus aureus hemB mutant is a small-colony variant which persists intracellularly.

@article{Eiff1997ASS,
  title={A site-directed Staphylococcus aureus hemB mutant is a small-colony variant which persists intracellularly.},
  author={Christof von Eiff and Christine Heilmann and Richard Anthony Proctor and Christian Woltz and Georg Peters and Friedrich G{\"o}tz},
  journal={Journal of bacteriology},
  year={1997},
  volume={179 15},
  pages={
          4706-12
        }
}
Although small-colony variants (SCVs) of Staphylococcus aureus have been recognized for many years, this phenotype has only recently been related to persistent and recurrent infections. Clinical S. aureus SCVs are frequently auxotrophic for menadione or hemin, two compounds involved in the biosynthesis of the electron transport chain elements menaquinone and cytochromes, respectively. While this observation as well as other biochemical characteristics of SCVs suggests a link between electron… CONTINUE READING
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