A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice.

@article{Neznanov1999AST,
  title={A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice.},
  author={Nickolay Neznanov and Albert K. Man and Hideyuki Yamamoto and C. A. Hauser and Robert Cardiff and Robert G. Oshima},
  journal={Cancer research},
  year={1999},
  volume={59 17},
  pages={4242-6}
}
Heterozygous female mice carrying a targeted mutation of the Ets2 transcription factor gene were mated with a mouse strain that develops mammary tumors due to the expression of the polyoma virus middle T oncogene. Tumors from females with only one wild-type Ets2 gene were approximately one-half the size of tumors from controls. The smaller size of the tumors was correlated with a more differentiated state of early hyperplastic growths and not to differential growth of the frank tumors or to… CONTINUE READING

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The histopathology of transgenes and knockouts in the mammary gland

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