A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice.

Abstract

Heterozygous female mice carrying a targeted mutation of the Ets2 transcription factor gene were mated with a mouse strain that develops mammary tumors due to the expression of the polyoma virus middle T oncogene. Tumors from females with only one wild-type Ets2 gene were approximately one-half the size of tumors from controls. The smaller size of the… (More)

Topics

3 Figures and Tables

Cite this paper

@article{Neznanov1999AST, title={A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice.}, author={N S Neznanov and Albert K. Man and Hisanori Yamamoto and C. A. Hauser and Robert Cardiff and Robert G. Oshima}, journal={Cancer research}, year={1999}, volume={59 17}, pages={4242-6} }