A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.

@article{Duthey2002ASS,
  title={A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.},
  author={B{\'e}atrice Duthey and Sara Caudron and Julie Perroy and Bernhard Bettler and Laurent Fagni and Jean-Philippe Pin and Laurent Pr{\'e}zeau},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 5},
  pages={
          3236-41
        }
}
Although G-protein-coupled receptors (GPCRs) have been shown to assemble into functional homo or heteromers, the role of each protomer in G-protein activation is not known. Among the GPCRs, the gamma-aminobutyric acid (GABA) type B receptor (GABA(B)R) is the only one known so far that needs two subunits, GB1 and GB2, to function. The GB1 subunit contains the GABA binding site but is unable to activate G-proteins alone. In contrast the GB2 subunit, which does not bind GABA, has an heptahelical… CONTINUE READING
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Coupling to G-protein in the GABAB Receptor 3241 by gest on N ovem er 4, 2016 hp://w w w .jb.org/ D ow nladed from Jean-Philippe Pin and Laurent Prézeau

R. B. Nehring, H.P.M. Horikawa, +6 authors A. Karschin
J. Biol. Chem • 2000