A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice.

@article{Hayashi2013ASS,
  title={A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice.},
  author={Atsushi Hayashi and Toshiro Sato and Nobuhiko Kamada and Yohei Mikami and Katsuyoshi Matsuoka and Tadakazu Hisamatsu and Toshifumi Hibi and Axel Roers and Hideo Yagita and Toshiaki Ohteki and Akihiko Yoshimura and Takanori Kanai},
  journal={Cell host & microbe},
  year={2013},
  volume={13 6},
  pages={
          711-22
        }
}
Imbalance in gut bacterial composition provokes host proinflammatory responses causing diseases such as colitis. Colonization with a mixture of Clostridium species from clusters IV and XIVa was shown to suppress colitis through the induction of IL-10-producing regulatory T (Treg) cells. We demonstrate that a distinct Clostridium strain from cluster I, Clostridium butyricum (CB), prevents acute experimental colitis in mice through induction of IL-10, an anti-inflammatory cytokine. However, while… CONTINUE READING
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