A single-site mutant and revertants arising in vivo define early steps in the pathogenesis of Venezuelan equine encephalitis virus.

@article{Aronson2000ASM,
  title={A single-site mutant and revertants arising in vivo define early steps in the pathogenesis of Venezuelan equine encephalitis virus.},
  author={Judith F. Aronson and Franziska B. Grieder and Nancy L. Davis and Peter C. Charles and Tim Knott and Keith William Brown and R. E. Johnston},
  journal={Virology},
  year={2000},
  volume={270 1},
  pages={111-23}
}
The early stages of Venezuelan equine encephalitis virus (VEE) pathogenesis in the mouse model have been examined using a genetic approach. Disease progression of a molecularly cloned single-site mutant was compared with that of the parental virus to determine the step in the VEE pathogenetic sequence at which the mutant was blocked. Assuming that such a block constitutes a genetic screen, isolates from different tissues thought to be distal to the block in the VEE pathogenetic sequence were… CONTINUE READING
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