A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter.

Abstract

The serotonin transporter (SERT) is a member of the Na+/Cl--dependent neurotransmitter transporter family and constitutes the target of several clinically important antidepressants. Here, replacement of serine-545 in the recombinant rat SERT by alanine was found to alter the cation dependence of serotonin uptake. Substrate transport was now driven as… (More)

Topics

8 Figures and Tables

Cite this paper

@article{Sur1997ASS, title={A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter.}, author={Comun del Sur and Heinrich Betz and Patrick D. Schloss}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1997}, volume={94 14}, pages={7639-44} }