A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase.

@article{Wilderman2007ASR,
  title={A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase.},
  author={P. R. Wilderman and R. J. Peters},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 51},
  pages={
          15736-7
        }
}
Terpene synthases often catalyze complex cyclization reactions that typically represent the committed step in particular biosynthetic pathways, leading to great interest in their enzymatic mechanisms. We have recently demonstrated that substitution of a specific Ile with Thr was sufficient to "short circuit" the complex cyclization reaction normally catalyzed by ent-kaurene synthases to instead produce ent-pimaradiene. Here we report that the complex cyclization/rearrangement reaction catalyzed… Expand
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