A single-quantum methyl 13C-relaxation dispersion experiment with improved sensitivity.

@article{Lundstrm2007ASM,
  title={A single-quantum methyl 13C-relaxation dispersion experiment with improved sensitivity.},
  author={Patrik Lundstr{\"o}m and Pramodh Vallurupalli and Tomasz L. Religa and Frederick W. Dahlquist and Lewis E. Kay},
  journal={Journal of biomolecular NMR},
  year={2007},
  volume={38 1},
  pages={79-88}
}
A pulse sequence is described for recording single-quantum (13)C-methyl relaxation dispersion profiles of (13)C-selectively labeled methyl groups in proteins that offers significant improvements in sensitivity relative to existing approaches where initial magnetization derives from (13)C polarization. Sensitivity gains in the new experiment are achieved by making use of polarization from (1)H spins and (1)H --> (13)C --> (1)H type magnetization transfers. Its utility has been established by… CONTINUE READING

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