A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte.

@article{Atri1993ASM,
  title={A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte.},
  author={A Atri and James F. Amundson and David Clapham and James Sneyd},
  journal={Biophysical journal},
  year={1993},
  volume={65 4},
  pages={1727-39}
}
We construct a minimal model of cytosolic free Ca2+ oscillations based on Ca2+ release via the inositol 1,4,5-trisphosphate (IP3) receptor/Ca2+ channel (IP3R) of a single intracellular Ca2+ pool. The model relies on experimental evidence that the cytosolic free calcium concentration ([Ca2+]c) modulates the IP3R in a biphasic manner, with Ca2+ release inhibited by low and high [Ca2+]c and facilitated by intermediate [Ca2+]c, and that channel inactivation occurs on a slower time scale than… CONTINUE READING
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