A single point mutation in the listerial betL σA-dependent promoter leads to improved osmo- and chill-tolerance and a morphological shift at elevated osmolarity

@inproceedings{Hoffmann2013ASP,
  title={A single point mutation in the listerial betL σA-dependent promoter leads to improved osmo- and chill-tolerance and a morphological shift at elevated osmolarity},
  author={Roland F Hoffmann and Susan McLernon and Audrey Feeney and Colin Hill and Roy D. Sleator},
  booktitle={Bioengineered},
  year={2013}
}
Betaine uptake in Listeria monocytogenes is mediated by three independent transport systems, the simplest of which in genetic terms is the secondary transporter BetL. Using a random mutagenesis approach, based on the E. coli XL1 Red mutator strain, we identified a single point mutation in a putative promoter region upstream of the BetL coding region which leads to a significant increase in betL transcript levels under osmo- and chill-stress conditions and a concomitant increase in stress… CONTINUE READING
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Analysis of the role of betL in contributing to the growth and survival of Listeria monocytogenes LO28

  • RD Sleator, CGM Gahan, B O’Driscoll, C. Hill
  • Int J Food Microbiol
  • 2000
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