A single point mutation in a group I WW domain shifts its specificity to that of group II WW domains.

@article{Espanel1999ASP,
  title={A single point mutation in a group I WW domain shifts its specificity to that of group II WW domains.},
  author={Xavier Espanel and Marius Sudol},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 24},
  pages={
          17284-9
        }
}
WW domains can be divided into three groups based on their binding specificity. By random mutagenesis, we switched the specificity of the Yes-associated protein (YAP) WW1 domain, a Group I WW domain, to that of the FE65 WW domain, which belongs to Group II. We showed that a single mutation, leucine 190 (betaB5) to tryptophan, is required to switch from Group I to Group II. Although this single substitution in YAP WW1 domain is sufficient to precipitate the two protein isoforms of Mena, an in… CONTINUE READING
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