A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.

@article{Goto1997ASM,
  title={A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.},
  author={Hidemasa Goto and Shigeru Motomura and Angus C Wilson and Richard N. Freiman and Yusaku Nakabeppu and Kohei Fukushima and Masatoshi Fujishima and Winship Herr and T Nishimoto},
  journal={Genes & development},
  year={1997},
  volume={11 6},
  pages={
          726-37
        }
}
The temperature-sensitive BHK21 hamster cell line tsBN67 ceases to proliferate at the nonpermissive temperature after a lag of one to a few cell divisions, and the arrested cells display a gene expression pattern similar to that of serum-starved cells. The temperature-sensitive phenotype is reversible and results from a single missense mutation--proline to serine at position 134--in HCF, a cellular protein that, together with the viral protein VP16, activates transcription of herpes simplex… CONTINUE READING

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