A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription.

@article{Lebrun1995ASP,
  title={A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription.},
  author={J J Lebrun and Samir Ali and Vincent Goffin and Axel Ullrich and Paul A. T. Kelly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 9},
  pages={4031-5}
}
Members of the cytokine/growth hormone/prolactin (PRL) receptor superfamily are associated with cytoplasmic tyrosine kinases of the Jak family. For the PRL receptor (PRLR), after PRL stimulation, both the kinase Jak2 and the receptor undergo tyrosine phosphorylation. To assess the role of tyrosine phosphorylation of the PRLR in signal transduction, several mutant forms of the PRLR in which various tyrosine residues were changed to phenylalanine were constructed and their functional properties… CONTINUE READING

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