A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair.

@article{Einhorn2003ASP,
  title={A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair.},
  author={Thomas A. Einhorn and Robert J. Majeska and Ahamed Mohaideen and Eric M Kagel and Mary L Bouxsein and Thomas J. Turek and John M. Wozney},
  journal={The Journal of bone and joint surgery. American volume},
  year={2003},
  volume={85-A 8},
  pages={1425-35}
}
BACKGROUND Recombinant human bone morphogenetic protein-2 (rhBMP-2), surgically implanted with a matrix material, has been shown to induce bone formation and enhance fracture repair. The purpose of this investigation was to test the hypothesis that a single, local, percutaneous injection of rhBMP-2 would accelerate fracture-healing in a standard rat femoral fracture model. METHODS Fractures were created, following intramedullary pinning, in the femora of 144 male Sprague-Dawley rats. The… CONTINUE READING

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