A single nucleotide polymorphism of Toll-like receptor 4 identifies the risk of developing graft failure after liver transplantation.

@article{Dhillon2010ASN,
  title={A single nucleotide polymorphism of Toll-like receptor 4 identifies the risk of developing graft failure after liver transplantation.},
  author={Navdeep Kaur Dhillon and Liron Walsh and Bernd Kr{\"u}ger and Stephen Geoffrey Ward and James H. Godbold and Mohamed Radwan and Thomas D. Schiano and Barbara T Murphy and Bernd Schr{\"o}ppel},
  journal={Journal of hepatology},
  year={2010},
  volume={53 1},
  pages={67-72}
}
BACKGROUND & AIMS While studies in animal models have linked Toll-like receptor (TLR) 4 signaling to the pathophysiology of ischemia/reperfusion (IR) injury and liver fibrosis, the relevance of TLR4 activation after human liver transplantation is unknown. The TLR4 single nucleotide polymorphism (SNP) D299G is situated within the extracellular domain and diminishes receptor binding to danger-associated molecular patterns. METHODS We studied the influence of TLR4 D299G on IR injury and graft… CONTINUE READING

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