A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription.

@article{Rutter1998ASN,
  title={A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription.},
  author={Joni L. Rutter and Teresa I Mitchell and Giovanna Buttic{\`e} and Jennifer M Meyers and James F. Gusella and Laurie Ozelius and Constance E. Brinckerhoff},
  journal={Cancer research},
  year={1998},
  volume={58 23},
  pages={5321-5}
}
Matrix metalloproteinases (MMPs) facilitate cellular invasion by degrading the extracellular matrix, and their regulation is partially dependent on transcription. Binding sites for members of the Ets family of transcription factors are present within MMP promoters and are potent positive regulators. We report a single nucleotide polymorphism at -1607 bp in the MMP-1 promoter, where an additional guanine (G) creates an Ets binding site, 5'-GGA-3'. This polymorphism displays significantly higher… CONTINUE READING
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