A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility.

@article{Ghilardi2002ASN,
  title={A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility.},
  author={Giorgio Ghilardi and Maria Luisa Biondi and Maria Rosaria Caputo and Simona Leviti and Marco DeMonti and Emma Guagnellini and Roberto Scorza},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 12},
  pages={3820-3}
}
PURPOSE Matrix metalloproteinases (MMPs) are likely to be involved in invasion and metastasis of several tumors by degrading the extracellular matrix. A single adenine insertion/deletion polymorphism (5A/6A) in the MMP-3 promoter region causes the elevation of transcriptional level and local expression of MMP-3. The aim of this pilot study was to evaluate the impact of this 5A/6A polymorphism on susceptibility and metastasis in breast cancer. EXPERIMENTAL DESIGN Genotyping for 5A/6A… CONTINUE READING

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