A single-nucleotide polymorphism in human angiotensinogen gene is associated with essential hypertension and affects glucocorticoid induced promoter activity

@article{Jain2004ASP,
  title={A single-nucleotide polymorphism in human angiotensinogen gene is associated with essential hypertension and affects glucocorticoid induced promoter activity},
  author={Sudhir Kumar Jain and Yanna Li and Sai Patil and Ashok Kumar},
  journal={Journal of Molecular Medicine},
  year={2004},
  volume={83},
  pages={121-131}
}
Hypertension is a serious health problem particularly for African-Americans. Previous studies have suggested that angiotensinogen (AGT) gene locus is involved in human essential hypertension. We have recently shown that an A/G polymorphism at −217 in the promoter of the AGT gene is associated with essential hypertension especially in African-Americans. We report here that A/G polymorphism at −217 affects the glucocorticoid-induced promoter activity of the human AGT gene. We show that… CONTINUE READING

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