A single nucleotide polymorphism in exon 1 of cytotoxic T-lymphocyte-associated-4 (CTLA-4) is not associated with rheumatoid arthritis.

@article{Barton2000ASN,
  title={A single nucleotide polymorphism in exon 1 of cytotoxic T-lymphocyte-associated-4 (CTLA-4) is not associated with rheumatoid arthritis.},
  author={Anne Barton and Anne Myerscough and Sally John and Miguel A Gonz{\'a}lez-Gay and William E. R. Ollier and Jane Worthington},
  journal={Rheumatology},
  year={2000},
  volume={39 1},
  pages={63-6}
}
BACKGROUND Rheumatoid arthritis (RA) is an oligogenic disease for which only one susceptibility locus has been identified to date. Genes involved in T-cell regulation are potential candidates. Association to cytotoxic T-lymphocyte-associated-4 (CTLA-4) protein, a negative regulator of T-cell activation, has previously been described in a subset of German RA patients carrying the HLA DRB1*0401 subtype. Linkage and association with another oligogenic autoimmune disease, insulin-dependent diabetes… CONTINUE READING