A single nucleotide change in the c-myc internal ribosome entry segment leads to enhanced binding of a group of protein factors

Abstract

A 340 nucleotide section of the c- myc 5' untranslated region (UTR) contains an internal ribosome entry segment. We have described previously a mutation in this region of RNA in cell lines derived from patients with multiple myeloma (MM) which exhibit increased expression of c- myc protein by an aberrant translational mechanism. In this study we show by… (More)
DOI: 10.1093/nar/26.13.3097

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