A single nonamer from the Yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in Yersinia-induced reactive arthritis.

@article{Ugrinovic1997ASN,
  title={A single nonamer from the Yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in Yersinia-induced reactive arthritis.},
  author={Sladjana Ugrinovic and A K Mertz and Peihua Wu and J{\"u}rgen Braun and Joachim Sieper},
  journal={Journal of immunology},
  year={1997},
  volume={159 11},
  pages={5715-23}
}
The reason for the high association of HLA-B27 with diseases such as ankylosing spondylitis and reactive arthritis is not clear. In reactive arthritis, the triggering bacteria are known, thus allowing investigation of their interaction with HLA-B27. CTL lines derived from five patients with Yersinia-induced reactive arthritis were raised by repeated stimulation in vitro with either Yersinia-infected autologous macrophages (four patients) or pooled peptides (three patients) having the HLA-B27… CONTINUE READING
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