A single mode of DNA base-pair opening drives imino proton exchange

@article{Guron1987ASM,
  title={A single mode of DNA base-pair opening drives imino proton exchange},
  author={Maurice Gu{\'e}ron and Michel Kochoyan and J A Leroy},
  journal={Nature},
  year={1987},
  volume={328},
  pages={89-92}
}
The opening of base pairs of double-stranded DNA is an important process, being a prerequisite for replication and transcription and possibly a factor in the recognition, flexibility and structure of DNA. The kinetics of base-pair opening have, however, been controversial. Base-pair opening can be studied by following the exchange of protons from imino groups with water, a process that seems only to occur from open base pairs. We have recently demonstrated catalysis by proton acceptors of imino… CONTINUE READING