A single mid-follicular dose of CDB-2914, a new antiprogestin, inhibits folliculogenesis and endometrial differentiation in normally cycling women.

@article{Stratton2000ASM,
  title={A single mid-follicular dose of CDB-2914, a new antiprogestin, inhibits folliculogenesis and endometrial differentiation in normally cycling women.},
  author={Pamela Stratton and B. J. Hartog and Niloufar Hajizadeh and Johann Piquion and Dorette Sutherland and Mar{\'i}a Merino and Young Jae Lee and Lynnette K Nieman},
  journal={Human reproduction},
  year={2000},
  volume={15 5},
  pages={1092-9}
}
Previous studies in women have shown that the antiprogestin mifepristone delays or inhibits folliculogenesis. The purpose of this study was to explore whether a new analogue, CDB-2914, has similar effects on folliculogenesis, ovulation, or on subsequent luteal phase endometrial maturation. Forty-four normally cycling, healthy women recorded urine LH and vaginal bleeding during pre-treatment, treatment, and post-treatment cycles. At a lead follicle diameter of 14-16 mm, a single oral dose (10… CONTINUE READING
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