A single internal ribosome entry site containing a G quartet RNA structure drives fibroblast growth factor 2 gene expression at four alternative translation initiation codons.

@article{Bonnal2003ASI,
  title={A single internal ribosome entry site containing a G quartet RNA structure drives fibroblast growth factor 2 gene expression at four alternative translation initiation codons.},
  author={Sophie Bonnal and C{\'e}line Schaeffer and Laurent Cr{\'e}ancier and Simone Clamens and Herv{\'e} Moine and A. Darder Prats and St{\'e}phan Vagner},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 41},
  pages={39330-6}
}
The 484-nucleotide (nt) alternatively translated region (ATR) of the human fibroblast growth factor 2 (FGF-2) mRNA contains four CUG and one AUG translation initiation codons. Although the 5'-end proximal CUG codon is initiated by a cap-dependent translation process, the other four initiation codons are initiated by a mechanism of internal entry of ribosomes. We undertook here a detailed analysis of the cis-acting elements defining the FGF-2 internal ribosome entry site (IRES). A thorough… CONTINUE READING