A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

@article{Gautam2016ASI,
  title={A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges},
  author={Rajeev Gautam and Yoshiaki Nishimura and Amarendra Pegu and Martha C. Nason and Florian Berger Ansgar Gr{\"u}ne Rolf Klein and Anna Gazumyan and Jovana Golijanin and ALICIA J. BUCKLER-WHITE and Reza Sadjadpour and Keyun Wang and Zachary Mankoff and Stephen D Schmidt and Jeffrey D Lifson and John R. Mascola and Michel C. Nussenzweig and Malcolm A Martin},
  journal={Nature},
  year={2016},
  volume={533},
  pages={105-109}
}
Despite the success of potent anti-retroviral drugs in controlling human immunodeficiency virus type 1 (HIV-1) infection, little progress has been made in generating an effective HIV-1 vaccine. Although passive transfer of anti-HIV-1 broadly neutralizing antibodies can protect mice or macaques against a single high-dose challenge with HIV or simian/human (SIV/HIV) chimaeric viruses (SHIVs) respectively, the long-term efficacy of a passive antibody transfer approach for HIV-1 has not been… CONTINUE READING
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