A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics

@article{Grima1987ASH,
  title={A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics},
  author={Brigitte Grima and Annie Lamouroux and Claudette Boni and J. F. Julien and France Javoy‐Agid and Jacques Mallet},
  journal={Nature},
  year={1987},
  volume={326},
  pages={707-711}
}
Catecholaminergic systems in discrete regions of the brain are thought to be important in affective psychoses, learning and memory, reinforcement and sleep–wake cycle regulation1. Tyrosine hydroxylase (TH) is the first enzyme in the pathway of catecholamine synthesis. Its importance is reflected in the diversity of the mechanisms that have been described which control its activity2; TH levels vary both during development and as a function of the activity of the nervous system. Recently, we… 
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It is concluded that common variation in the proximal TH promoter is functional, giving rise to changes in autonomic function and consequently cardiovascular risk.
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TLDR
There is alternative splicing of the TH primary transcript, and putative additional poisttranslational regulation may yield TH proteins with no enzymatic activity, at least in non‐catecholaminergic tissues.
Cloning and cell type-specific regulation of the human tyrosine hydroxylase gene promoter.
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TLDR
Tyrosine hydroxylase catalyzes the first and rate‐limiting step in the biosynthesis of catecholamines, and alternative splicing of TH primary transcript has been described as a characteristic of higher primates and Drosophila.
The human tyrosine hydroxylase gene
  • T. Nagatsu
  • Biology
    Cellular and Molecular Neurobiology
  • 2004
TLDR
The results of Southern blot analysis and the nucleotide sequence of the human TH genomic DAN indicate that the four types of human TH mRNA are produced through alternative splicing from a single gene.
Isolation and nucleotide sequence of a cDNA clone encoding bovine adrenal tyrosine hydroxylase: Comparative analysis of tyrosine hydroxylase gene products
TLDR
Comparison of the size of bovine and rat TH mRNA and protein by northern blot and immunoblot analyses yielded differences consistent with those predicted from the nucleotide sequence data.
Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients
TLDR
The results indicate that exon 3 of the human TH gene lacks association with schizophrenia in Japanese patients, and any mutation changing the amino acid sequence Gly36-Arg37-Arg38 would result in the elevation of DA synthesis.
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TLDR
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TLDR
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TLDR
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