A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics
@article{Grima1987ASH, title={A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics}, author={Brigitte Grima and Annie Lamouroux and Claudette Boni and J. F. Julien and France Javoy‐Agid and Jacques Mallet}, journal={Nature}, year={1987}, volume={326}, pages={707-711} }
Catecholaminergic systems in discrete regions of the brain are thought to be important in affective psychoses, learning and memory, reinforcement and sleep–wake cycle regulation1. Tyrosine hydroxylase (TH) is the first enzyme in the pathway of catecholamine synthesis. Its importance is reflected in the diversity of the mechanisms that have been described which control its activity2; TH levels vary both during development and as a function of the activity of the nervous system. Recently, we…
331 Citations
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