A single heteroclitic epitope determines cancer immunity after xenogeneic DNA immunization against a tumor differentiation antigen.

@article{Gold2003ASH,
  title={A single heteroclitic epitope determines cancer immunity after xenogeneic DNA immunization against a tumor differentiation antigen.},
  author={Jason S Gold and Cristina R Ferrone and Jose Guevara-patino and W. G. Hawkins and Ruben Dyall and Manuel E. Engelhorn and Jedd D Wolchok and Jonathan James Muschamp Lewis and AlanN. Houghton},
  journal={Journal of immunology},
  year={2003},
  volume={170 10},
  pages={
          5188-94
        }
}
Successful active immunization against cancer requires induction of immunity against self or mutated self Ags. However, immunization against self Ags is difficult. Xenogeneic immunization with orthologous Ags induces cancer immunity. The present study evaluated the basis for immunity induced by active immunization against a melanoma differentiation Ag, gp100. Tumor rejection of melanoma was assessed after immunization with human gp100 (hgp100) DNA compared with mouse gp100 (mgp100). C57BL/6… CONTINUE READING
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