A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding.

@article{Symmans2005ASB,
  title={A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding.},
  author={W. Fraser Symmans and Derek J. Fiterman and Stephen K Anderson and Mark L. Ayers and R{\'e}gine Rouzier and Valerie Dunmire and Jim Stec and Vincete Valero and Nour Sneige and C. Gonz{\'a}lez Albarracin and Yu-peng Wu and Jerret Ross and Philipp Wagner and Rachel Leigh Theriault and Balakrishnan Arun and Henry Mark Kuerer and Kenneth R. Hess and Wanfan Zhang and Gabriel N Hortobagyi and Lajos Pusztai},
  journal={Endocrine-related cancer},
  year={2005},
  volume={12 4},
  pages={
          1059-69
        }
}
The pathogenesis of breast cancers that do not express estrogen receptors or Her-2/neu receptors (ER-/HER2- phenotype) is incompletely understood. We had observed markedly elevated gene expression of gamma-aminobutyric acid type A (GABA(A)) receptor subunit pi (GABApi, GABRP) in some breast cancers with ER-/HER2- phenotype. In this study, transcriptional profiles (TxPs) were obtained from 82 primary invasive breast cancers by oligonucleotide microarrays. Real-time reverse transcription… CONTINUE READING

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Highly Influential
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