A single gene and a pseudogene for the cellular tumour antigen p53

  title={A single gene and a pseudogene for the cellular tumour antigen p53},
  author={R. Zakut-Houri and M. Oren and B. Bienz and V. Lavie and S. Hazum and D. Givol},
  • R. Zakut-Houri, M. Oren, +3 authors D. Givol
  • Published 1983
  • Biology, Medicine
  • Nature
  • The cellular tumour antigen p53 is a protein found in elevated levels in a great variety of transformed cells (reviewed in ref. 1). Overproduction of p53 was observed in cells transformed by a wide spectrum of agents2–7 as well as in embryonal carcinoma cells3,8 and in spontaneous transformants9,10. Although initially described in mice2,3,9, similar p53-like proteins were also observed in cells of other species, including those derived from several human tumours11. In non-transformed cells the… CONTINUE READING
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