A single functional group substitution in c5a breaks B cell and T cell tolerance and protects against experimental arthritis.

Christoph Von Kessel; Kutty Selva Nandakumar; Francis B. Peters; Varun Gauba; Peter G. Schultz; Rikard Holmdahl

Medicine
Published in Arthritis & rheumatology 2014
DOI:10.1002/art.38237

A single functional group substitution in c5a breaks B cell and T cell tolerance and protects against experimental arthritis.

@article{Kessel2014ASF,
  title={A single functional group substitution in c5a breaks B cell and T cell tolerance and protects against experimental arthritis.},
  author={Christoph Von Kessel and Kutty Selva Nandakumar and Francis B. Peters and Varun Gauba and Peter G. Schultz and Rikard Holmdahl},
  journal={Arthritis & rheumatology},
  year={2014},
  volume={66 3},
  pages={
          610-21
        }
}

Christoph Von Kessel, Kutty Selva Nandakumar, +3 authors Rikard Holmdahl

OBJECTIVE A deficiency in C5 protects against arthritis development. However, there is currently no approach successfully translating these findings into arthritis therapy, as by targeting the key component, C5a. The aim of this study was to develop a vaccination strategy targeting C5a as therapy for patients with rheumatoid arthritis. METHODS An anti-C5a vaccine was generated by incorporating the unnatural amino acid p-nitrophenylalanine (4NPA) into selected sites in the murine C5a molecule… CONTINUE READING

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